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PGTA (Preimplantation Genetic Testing for Aneuploidies)

PGTA (Preimplantation Genetic Testing for Aneuploidies)

PGTA (Preimplantation Genetic Testing for Aneuploidies) is an advanced genetic screening technique performed during IVF to check embryos for chromosomal abnormalities. Aneuploidies occur when an embryo has too many or too few chromosomes, which can lead to failed implantation, miscarriage, or genetic conditions such as Down syndrome. PGTA ensures only chromosomally normal embryos are selected for transfer, improving the chances of a healthy pregnancy.

When to Consider PGTA?

  • For women of advanced maternal age (above 35 years)
  • In cases of recurrent IVF failures
  • For couples with a history of recurrent miscarriages
  • When there is a known risk of chromosomal abnormalities
  • To improve success rates in fertility treatments
  • If recommended by a fertility specialist after evaluation

How is PGTA Performed?

  • Embryo Culture: Embryos are grown to the blastocyst stage in the lab.
  • Embryo Biopsy: A few cells are carefully removed from the trophectoderm layer.
  • Genetic Testing: Advanced methods like Next-Generation Sequencing (NGS) analyze the chromosomes.
  • Embryo Freezing: Embryos are frozen while results are awaited.
  • Embryo Transfer: Only chromosomally normal embryos are selected for transfer to the uterus.

Benefits of PGTA

  • Increases IVF success rates by selecting healthy embryos
  • Reduces the risk of miscarriage due to chromosomal errors
  • Helps avoid transfer of embryos with chromosomal abnormalities
  • Improves chances of having a healthy baby
  • Provides reassurance and confidence to couples undergoing IVF

Risks Involved

  • Minimal risk of embryo damage during biopsy
  • Not all genetic abnormalities can be detected
  • Emotional stress if abnormal results are found
  • Cost implications for advanced testing

Advanced Technology

PGTA uses cutting-edge techniques like Next-Generation Sequencing (NGS), Comparative Genomic Hybridization (CGH), and microarray analysis to accurately detect aneuploidies. This ensures the transfer of only the healthiest embryos, leading to higher success rates and improved pregnancy outcomes.

Expert Consultation