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PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements)

PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements)

PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements) is a specialized form of embryo testing during IVF that identifies chromosomal structural abnormalities such as translocations, inversions, and deletions. Couples carrying these structural rearrangements often face recurrent miscarriages or failed IVF attempts. PGT-SR helps in selecting embryos with normal chromosomal structure, significantly improving the chances of a successful pregnancy and healthy live birth.

When to Consider PGT-SR?

  • For couples with a history of recurrent pregnancy losses
  • When one or both partners are carriers of balanced chromosomal translocations
  • In cases of repeated IVF or implantation failures
  • When structural chromosomal abnormalities are suspected
  • If recommended after genetic counseling and testing

How is PGT-SR Performed?

  • Embryo Development: Embryos are created through IVF and grown to the blastocyst stage.
  • Embryo Biopsy: A few cells are carefully removed from the outer layer of the embryo (trophectoderm).
  • Chromosomal Analysis: Advanced genetic techniques such as Next-Generation Sequencing (NGS) detect chromosomal structural abnormalities.
  • Embryo Selection: Only chromosomally normal embryos are chosen for transfer.
  • Embryo Transfer: Healthy embryos are transferred to the uterus to increase pregnancy success.

Benefits of PGT-SR

  • Helps identify embryos with normal chromosomal structure
  • Reduces the risk of miscarriage caused by structural abnormalities
  • Improves IVF success rates for affected couples
  • Ensures healthier embryo selection for transfer
  • Provides reassurance for couples with chromosomal rearrangements

Risks Involved

  • Minimal risk of embryo damage during biopsy
  • May not detect very small chromosomal changes
  • Emotional stress if few or no healthy embryos are available
  • Requires advanced lab facilities and expert handling

Advanced Technology

PGT-SR utilizes cutting-edge techniques like Next-Generation Sequencing (NGS) and microarray analysis to identify chromosomal structural abnormalities with high precision. This advanced technology ensures that only embryos with correct chromosomal arrangements are transferred, leading to better pregnancy outcomes.

Expert Consultation