PGT-M (Preimplantation Genetic Testing for Monogenic Diseases)

When to Consider PGT-M?

• For couples with a known family history of single-gene disorders
• When one or both partners are carriers of a genetic condition
• In cases of repeated pregnancy losses due to genetic abnormalities
• When previous children are affected by genetic diseases
• If recommended by a genetic counselor or fertility specialist

How is PGT-M Performed?

• Embryo Development: Embryos are created using IVF.
• Embryo Biopsy: A few cells are taken from the embryo at the blastocyst stage.
• DNA Analysis: The cells undergo genetic testing to detect the specific monogenic disorder.
• Embryo Selection: Only embryos free from the disorder are chosen for transfer.
• Embryo Transfer: Healthy embryos are transferred to the uterus to achieve pregnancy.

Benefits of PGT-M

• Prevents the transmission of serious inherited diseases
• Increases chances of having a healthy child
• Reduces emotional and financial burden of managing genetic disorders
• Provides reassurance for couples with genetic risk factors

Risks Involved

• Minimal risk of embryo damage during biopsy
• May not detect all possible mutations
• Emotional challenges if no healthy embryos are available
• Requires highly specialized laboratories and expertise

Advanced Technology

PGT-M uses advanced molecular diagnostic methods, such as Next-Generation Sequencing (NGS) and Polymerase Chain Reaction (PCR), to identify single-gene mutations with high accuracy. This ensures couples can have healthy children without passing on monogenic diseases.