Multiple IVF Failure

Multiple IVF Failures - Causes & Failures

Repeated IVF failure is defined as the inability to achieve a clinical pregnancy after the transfer of at least four good-quality embryos over a minimum of three fresh or frozen cycles in women under the age of 40. Although most Assisted Reproductive Technology (ART) clinics report implantation rates between 40–60%, exact figures vary due to differing definitions of implantation.

Several factors may contribute to repeated IVF failure. These include embryo-related issues, parental chromosomal abnormalities leading to abnormal embryo development, or oocyte aneuploidies, often associated with advanced maternal age.

Causes of Multiple IVF Failure -

High sperm DFI (DNA Fragmentation Index)
Intra-Uterine adhesions (scar tissue)
Congenital abnormalities in uterus
Presence of Hydrosalpinx
Fibroids Adenomyosis
Thin endometrium
Autoantibodies
High BMI
Polyps
Defective endometrial receptivity
Immunological factors

Precautions to Consider During IVF Treatment:

Take injections and medications consistently as prescribed.
Refrain from sexual intercourse after 6-7 days of starting the injections.
Steer clear of smoking, alcohol, and habit-forming substances.
Avoid lifting heavy weights or engaging in activities that may increase intra-abdominal pressure.
Follow a balanced and healthy diet plan.
Practice stress management techniques to support your treatment.

Understanding and Overcoming Repeated IVF Failure

Before exploring treatment options, it’s essential to identify the underlying causes of repeated IVF failure. A thorough uterine evaluation, often performed through hysteroscopy, can help detect structural or functional issues. Additionally, the Endometrial Receptivity Array (ERA) is a valuable tool used to determine the optimal time for embryo transfer by assessing when the uterus is most receptive.

In cases where high sperm DNA fragmentation (DFI) is a contributing factor, advanced techniques such as MACS (Magnetic-Activated Cell Sorting) during ICSI can be used to select healthier sperm with lower DFI, potentially improving outcomes.

Alongside medical intervention, couples are encouraged to adopt a healthy lifestyle—including a balanced diet, regular yoga or exercise, meditation, and avoiding smoking, alcohol, and other harmful substances. Choosing an experienced IVF consultant and a reputable fertility center can also reduce stress and improve the chances of success. Following medical guidance diligently plays a crucial role in achieving better results.

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