AMH (Anti Mullerian Horomone)
Anti-Mullerian Hormone (AMH) is a hormone secreted by cells in developing egg sacs (follicles). The level of AMH in a woman’s blood is generally a good indicator of her ovarian reserve.
AMH is produced solely in the granulosae cells of pre antral and antral ovarian follicles. Measuring the AMH levels gives an indication of the size of the cohort.
The number of antral follicles (the cohort) size, correlates with fertility potential. Young women, who normally have better fertility, will normally have a larger number of antral follicles visible on ultrasound and higher AMH levels.
Low anti-Mullerian hormone and high follicle stimulating hormone levels are indicators of diminished ovarian reserve (DOR), a decline in the ovaries’ ability to produce good-quality eggs. DOR is one of the major causes of infertility among women. In reverse, high AMH can signal polycystic ovary syndrome (PCOS)
The level of AMH in the blood can help to estimate the number of follicles inside the ovaries, and therefore, the woman’s egg count. A typical AMH level for a fertile woman is 1.0–4.0 ng/ml; under 1.0 ng/ml is considered low and indicative of a diminished ovarian reserve.
The study found women with high AMH levels were 2.5 times more likely to have a successful IVF cycle than women of a similar age with low levels of the hormone. … “High levels of this hormone mean there is a greater chance they have plenty of healthy eggs remaining to support a pregnancy.”
Women with PCOS have higher level of AMH, and therefore have high number of small (antral and preantral) follicles and at risk of developing OHSS with hormonal stimulation.